The absence of Vitamin-C from human diet causes scurvy in three or four months. Major symptoms of this disease are general weakness, swelling of gums and loosening of the teeth, many small hemorrhages into the skin and mucus membranes, and brittleness of bones. If not soon treated the disease is fatal. In the absence of Vitamin-C the capillary walls become fragile or abnormally permeable, causing extracasation of blood into the tissues.